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Fig. 5 | BMC Urology

Fig. 5

From: Identification of ferroptosis related genes and pathways in prostate cancer cells under erastin exposure

Fig. 5

Prediction and validation the expression of TFs targeting hub genes and the clinical characteristics of the essential hub genes. (a) Top 10 hub DEGs of the LNCaP and PC3 cell groups with erastin treatment. (b) Interaction network of hub genes and their TFs. (c) The heatmap of the expression of the TFs was revealed by RNA-seq. (d) Expression of hub DEGs and TFs after erastin treatment were measured by qPCR, n = 3. The expression levels of TMEFF2, CLU, NRXN3, and UNC5B in normal tissues and prostate cancer tissue from the HPA database (e) and GEPIA database (f). *p < 0.05, *p < 0.01, ***p < 0.001

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BMC Urology

ISSN: 1471-2490

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