Current updates relating to treatment for interstitial cystitis/bladder pain syndrome: systematic review and network meta-analysis

Table 1 Effects of moderators for interstitial cystitis in pairwise meta-analysis

	Pain						Frequency						Urgency						Nocturia
Variables	k	β	SMD	95% CI		p	k	β	SMD	95% CI		P	k	β	SMD	95% CI		p	k	β	SMD	95% CI		p
No. of total patients	27	0.004		0.000	0.009	0.08	27	0.003		-0.002	0.008	0.21	14	0.008		-0.002	0.019	0.10	9	0.025		-0.004	0.053	0.09
Age	25	0.010		-0.022	0.041	0.56	24	0.007		-0.022	0.036	0.63	13	-0.058		-0.136	0.019	0.14	7	0.063		0.019	0.107	0.005
Follow up period (month)	26	-0.027		-0.076	0.022	0.28	27	-0.040		-0.071	-0.008	0.014	13	-0.030		-0.154	0.094	0.63	9	-0.037		-0.075	0.001	0.06
Treatment						0.09						0.27						0.96						0.50
Medication or system injection	7		-0.278	-0.662	0.066		10		-0.012	-0.253	0.230		7		-0.478	-1.057	0.102		2		-0.177	-0.813	0.458
Instillation	8		-0.314	-0.639	0.011		11		-0.282	-0.531	-0.034		3		-0.213	-1.132	0.706		4		-0.628	-1.127	-0.129
Intravesical injection	8		-0.556	-0.888	-0.224		5		-0.264	-0.650	0.122		1		-0.314	-1.790	1.161		3		-0.305	-0.815	0.205
Physical therapy	1		-0.660	-1.529	0.208
Others	3		0.336	-0.217	0.888		1		0.397	-0.559	1.352		3		-0.523	-1.420	0.373
Country						0.18						0.14						0.38						0.24
Western	17		-0.38z	-0.612	-0.149		19		-0.079	-0.237	0.080		12		-0.332	-0.713	0.049		4		-0.482	-0.884	-0.079
Eastern	9		-0.146	-0.471	0.179		7		-0.228	-0.512	0.056		2		-0.767	-1.667	0.134		4		-0.191	-0.534	0.152
Middle East	1		-1.151	-2.276	-0.025		1		-0.958	-1.882	-0.034								1		-0.933	-1.823	-0.043
Cystoscopy						0.49						0.92						0.010
Yes	18		-0.376	-0.614	-0.139		22		-0.146	-0.321	0.028		5		0.065	-0.365	0.495
No	9		-0.235	-0.562	0.091		5		-0.168	-0.544	0.208		9		-0.685	-1.059	-0.311
Hunner lesion						0.65						0.68						0.104						0.36
HL+/HL-	6		-0.477	-0.912	-0.041		10		-0.118	-0.393	0.156		3		0.196	-0.441	0.832		3		-0.644	-1.108	-0.179
HL-	8		-0.371	-0.724	-0.018		5		-0.326	-0.737	0.084		1		-0.314	-1.439	0.810		3		-0.278	-0.705	0.148
N/A	13		-0.242	-0.520	0.036		12		-0.13	-0.39	0.13		10		-0.62	-1.008	-0.221		3		-0.23	-0.62	0.17

k number of effect sizes, β regression coefficient, SMD standardized mean difference, p-value from meta-regression analysis using the restricted maximum likelihood

ISSN: 1471-2490