Leiomyosarcoma presenting as a spontaneously ruptured renal tumor-case report
© Moazzam et al; licensee BioMed Central Ltd. 2002
Received: 11 September 2002
Accepted: 19 November 2002
Published: 19 November 2002
Ruptured renal neoplasms can be a catastrophic clinical presentation. Angiomyolipoma is the commonest renal tumor which presents in this fashion. Renal sarcomas are rare renal neoplasms. Renal leiomyosarcomas are the most common histological subtype of renal sarcomas, accounting for approximately 50–60% of the reported cases. These tumors are usually peripherally located and appear to arise from either the renal capsule or smooth muscle tissue in the renal pelvic wall.
A 70 years old male, with hypertension and ischemic disease, developed acute left flank pain. The general physician evaluated this using ultrasound, which showed a solid left renal mass. Two weeks later, he presented in the emergency room in a state of shock with a palpable flank mass. CT scan of the abdomen showed a large heterogeneous mass lesion in the left perinephric space with minimal post contrast enhancement. Per-operatively, large retroperitoneal hematoma was found within Gerota's fascia along with spleen plastered to the upper limit of hematoma. Nephrectomy and splenectomy were performed. Postoperative course was uneventful and patient was discharged on the 10th post-operative day. Histopathological evaluation of the specimen showed high-grade leiomyosarcoma
Spontaneous rupture of renal neoplasm is a rare clinical presentation. Angiomyolipoma is the commonest cause of spontaneous rupture of the kidney. Presentation of a leimyosarcoma as a ruptured renal neoplasm has not been previously reported in the English literature.
KeywordsNon-traumatic kidney rupture kidney tumor sarcoma
Leiomyosarcomas of the kidney make up to 0.5–1.5% of malignant renal tumors in adults . There is no difference in the gender distribution with a mean age at diagnosis in the sixth decade. They typically presents with the classical triad of symptoms i.e. flank pain, hematuria, and abdominal mass mimicking renal cell carcinoma. Radiological findings are nonspecific and diagnosis is usually made postoperatively.
Spontaneous rupture of renal neoplasm is commonly seen for large angiomyolipoma, occasional case report also describes cases of renal cell cancers and Wilm's tumor. Ruptured renal leiomyosarcoma is not previously reported in English literature. In non-English literature, there are two cases [2, 3]. Yoshikawa et al reported a case of a spontaneously ruptured renal leiomyosarcoma, treated by nephrectomy followed by immuno-chemotherapy and radiotherapy . At 18 months, follow up of patient was free of local recurrence and distant metastasis. Kyuno et al reported a case of spontaneous rupture of leiomyosarcoma, who died 2 months after nephrectomy of intestinal perforation.
A 70 years old male, known case of hypertension and ischemic disease, developed acute left flank pain, the general physician evaluated this by an ultrasound that showed a solid left renal mass. He was referred to this hospital for further evaluation, however, he presented in the emergency room with sudden onset of severe central abdominal pain, radiating to left flank increasing with movement and associated with two episodes of non-bilious vomiting. On clinical examination patient was haemodynamically stable, pale looking, with a bi-manually palpable left flank mass, extending to right hypochondrium. Initial laboratory work up showed a low Hemoglobin 6.1 g/dl (13.7–16.3), urinalysis showed microscopic haematuria, and serum creatinine 1.8 mg/dl.
Spontaneous rupture of renal neoplasm is a rare clinical presentation. Angiomyolipoma are the commonest cause of spontaneous rupture of kidney. Presentation of a leimyosarcoma as a ruptured renal neoplasm has not been previously reported in English literature.
Leiomyosarcomas even when confined to the kidney have a poor prognosis. Radical surgery offers the best chance of cure; role of adjuvant chemo-immunotherapy and/or radiotherapy remains debatable, due to paucity of data on the treatment of this rare renal neoplasm and divergent results from limited experience in literature.
Written consent was obtained from the patient's relative for publication of the patient's details.
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- Yoshikawa M, Hayashi Y, Sanma S, Maruyama Y, Hirao Y, Okajima E: Spontaneous rupture of renal leiomyosarcoma: report of a case. Hinyokika-Kiyo. 1986, 32 (9): 1282-7.PubMedGoogle Scholar
- Kyuno H, Iwamura M, Muramoto M, Kou H, Koshiba K: A case of spontaneous rupture of renal leiomyosarcoma. Hinyokika-Kiyo. 1996, 42 (8): 583-6.PubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2490/2/13/prepub
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