Table 3 Stratified analyses of pooled relative risk of fractures for patients under androgen deprivation therapy
From: A systematic review and meta-analysis of bone metabolism in prostate adenocarcinoma
Stratified Analysis | Patients | Pooled RR (95% CI) | Heterogeneity |
|---|---|---|---|
Incidence of fractures as the primary outcome | |||
Yes | 111,573 | 1.17 (1.14 - 1.20) | 0.0001 |
No | --- | --- | --- |
Type of outcome measure | |||
Self-reported | 50,613 | 1.06 (1.02 - 1.10) | Not applicable |
Ambulatorial | 22,802 | 1.18 (1.12 - 1.24) | 0.02 |
Bone metastases in the sample | |||
Yes | 50,678 | 1.06 (1.02 - 1.10) 1.18 | 0.09 |
No | 22,737 | (1.12 - 1.23) | 0.01 |
Mean follow-up, y | |||
≥ 5 | 61,295 | 1.08 (1.04 - 1.11) | 0.04 |
< 5 | 12,120 | 1.29 (1.18 - 1.43) | Not applicable |
Type of fracture | |||
Lumbar spine fracture | 74,394 | 1.33 (1.22 - 1.45) | 0.93 |
Inferior member fracture | 74,394 | 1.15 (1.10 - 1.20) | 0.001 |