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Table 3 Stratified analyses of pooled relative risk of fractures for patients under androgen deprivation therapy

From: A systematic review and meta-analysis of bone metabolism in prostate adenocarcinoma

Stratified Analysis Patients Pooled RR (95% CI) Heterogeneity
Incidence of fractures as the primary outcome    
   Yes 111,573 1.17 (1.14 - 1.20) 0.0001
   No --- --- ---
Type of outcome measure    
   Self-reported 50,613 1.06 (1.02 - 1.10) Not applicable
   Ambulatorial 22,802 1.18 (1.12 - 1.24) 0.02
Bone metastases in the sample    
   Yes 50,678 1.06 (1.02 - 1.10) 1.18 0.09
   No 22,737 (1.12 - 1.23) 0.01
Mean follow-up, y    
   ≥ 5 61,295 1.08 (1.04 - 1.11) 0.04
   < 5 12,120 1.29 (1.18 - 1.43) Not applicable
Type of fracture    
   Lumbar spine fracture 74,394 1.33 (1.22 - 1.45) 0.93
   Inferior member fracture 74,394 1.15 (1.10 - 1.20) 0.001