Figure 5

Representative data of ROS urine cytology. (A) Atypical urothelial cell cluster was found under bright field, and these cells were reactive to CM-DCFDA and DHE as determined under fluorescence filed (C-C is poitive and ROS-C is positive). Histological examination of bladder tumors (H&E) revealed superficially invasive/high grade urothelial carcinoma (pT1). (B) Cluster of atypical small sized urothelial cells were found under bright field, but intracellular ROS was not determined (C-C is 'suspicious' but ROS-C is negative). Histology of bladder specimen (H&E) revealed denuding cystitis without malignant findings.