Table 3 Relative expression of the genes in the malignant bladder tissue according to grade, Pathological stage and angiolinfatic invasion
From: Increased expression of MMP-9 and IL-8 are correlated with poor prognosis of Bladder Cancer
Grade Median (min-max) | Pathological Stage Median (min-max) | Angiolinfatic Invasion Median (min-max) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Genes | Low (n=18) | High (n=22) | p | pTa (n=19) | pT1 (n=13) | pT2 (n=8) | p | Without (n=36) | With (n=4) | p |
MMP2 | 0.125(0.50-2.10) | 0.166(0.02-1.60) | 0.904 | 0.165(0.05-2.10) | 0.109(0.02-0.34) | 0.226(0.05-1.60) | 0.200 | 0.130 (0.02-2.10) | 0.229 (0.13-0.67) | 0.148 |
MMP9 | 0.680(0.05-38.9) | 3.291(0.03-125.1) | 0.012 | 0.687(0.00-38.9) | 8.532 (0.00-125) | 2.938(0.18-25.8) | 0.048 | 1.250 (0.00-125) | 2.938 (1.01-13.2) | 0.333 |
TIMP1 | 0.489(0.10-4.02) | 0.508(0.07-12.01) | 1.000 | 0.398(0.10-4.02) | 0.326 (0.07-4.13) | 0.967(0.16-12.0) | 0.169 | 0.443 (0.07-12.0) | 0.978 (0.44-1.91) | 0.148 |
TIMP2 | 0.076(0.01-8.42) | 0.110(0.01-32.5) | 0.427 | 0.077(0.01-8.42) | 0.090(0.01-0.47) | 0.255(0.01-32.5) | 0.247 | 0.085 (0.01-32.5) | 0.255 (0.09-0.84) | 0.101 |
MMP14 | 0.469(0.02-2.87) | 0.493(0.14-30.4) | 0.798 | 0.516(0.29-2.87) | 0.336 (0.14-1.67) | 0.756(0.02-30.4) | 0.08 | 0.464 (0.02-30.4) | 0.540 (0.46-1.62) | 0.557 |
RECK | 0.175(0.00-1.65) | 0.129(0.01-0.88) | 0.606 | 0.224(0.00-1.65) | 0.046 (0.01-0.88) | 0.240(0.01-0.71) | 0.953 | 0.224 (0.00-1.65) | 0.09(0.03-0.35) | 0.772 |
IL8 | 0.075(0.00-37.2) | 0.783(0.01-13.63) | 0.003 | 0.087(0.00-37.2) | 0.750 (0.02-13.6) | 2.042(0.01-12.9) | 0.015 | 0.132 (0.00-37.2) | 2.412 (0.30-5.85) | 0.161 |