Table 3 Acute adverse events according to NCI-CTC
| Â | Docetaxel with estramustine | Docetaxel without estramustine | Â | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Â | (n = 33) | (n = 28) | Â | ||||||
| Â | Any grade* | Grade3-4 | Any grade | Grade3-4 | p value** | ||||
| Â | n | % | n | % | n | % | n | % | Â |
Leukopenia | 15 | 45 | 7 | 21 | 18 | 64 | 11 | 39 | 0.123 |
Neutropenia | 13 | 39 | 11 | 33 | 19 | 68 | 14 | 50 | 0.187 |
Febrile neutropenia | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 0.353 |
Anemia | 9 | 27 | 1 | 3 | 5 | 18 | 2 | 7 | 0.443 |
Thrombocytopenia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ne |
Fatigue | 10 | 30 | 0 | 0 | 10 | 36 | 0 | 0 | ne |
Anorexia | 10 | 30 | 0 | 0 | 10 | 36 | 1 | 4 | 0.274 |
Nausea | 13 | 39 | 2 | 6 | 10 | 36 | 0 | 0 | 0.185 |
Diarrhea | 4 | 12 | 0 | 0 | 2 | 7 | 0 | 0 | ne |
Taste alteration | 1 | 3 | 0 | 0 | 1 | 4 | 0 | 0 | ne |
Dizziness | 3 | 9 | 0 | 0 | 2 | 7 | 0 | 0 | ne |
Flushing | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | ne |
Edema | 1 | 3 | 0 | 0 | 2 | 7 | 0 | 0 | ne |
AST/ALT | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | ne |
Allergic reaction | 1 | 3 | 1 | 3 | 1 | 4 | 0 | 0 | 0.353 |
Pulmonary fibrosis | 1 | 3 | 1 | 3 | 0 | 0 | 0 | 0 | 0.353 |
Hair loss | 14 | 42 | 0 | 0 | 12 | 43 | 0 | 0 | ne |
Mood alteration | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | ne |
Neuropathy | 1 | 3 | 0 | 0 | 1 | 4 | 0 | 0 | ne |
Thromboembolic event | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | ne |