Prognostic value of changes in quality of life scores in prostate cancer

BMC Urology

Table 4 Baseline QoL measures and associated HRs for death

Baseline variable	QoL score mean (SD)	Univariate		Multivariate
		HR (95% CI)	P	HR (95% CI)	P
General quality of life
Global	65.8 (25.7)	0.85 (0.74 – 0.96)	0.007*	0.92 (0.80 – 1.04)	0.19
General function
Physical	84.6 (20.7)	0.81 (0.70 – 0.92)	0.001*	0.83 (0.64 – 1.03)	0.09
Role	81.7 (28.1)	0.87 (0.78 – 0.96)	0.006*	1.12 (0.88 – 1.37)	0.32
Emotional	74.5 (23.5)	0.98 (0.85 – 1.11)	0.78	0.97 (0.73 – 1.22)	0.84
Cognitive	82.8 (22.1)	1.02 (0.88 – 1.17)	0.74	1.36 (0.99 – 1.51)	0.07
Social	80.2 (27.1)	0.90 (0.80 – 1.01)	0.08	1.04 (0.84 – 1.24)	0.72
General symptom
Fatigue	28.6 (26.8)	1.16 (1.06 – 1.27)	0.002*	1.45 (1.19 – 1.73)	0.001*
Nausea/Vomiting	5.8 (14.6)	1.12 (0.98 – 1.26)	0.08	0.88 (0.55 – 1.23)	0.50
Pain	22.4 (28.5)	1.16 (1.06 – 1.26)	0.001*	1.09 (0.92 – 1.26)	0.31
Dyspnea	15.0 (22.3)	0.98 (0.83 – 1.13)	0.78	0.88 (0.71 – 1.05)	0.17
Insomnia	29.2 (29.3)	1.01 (0.90 – 1.13)	0.82	0.99 (0.82 – 1.16)	0.89
Appetite loss	12.5 (23.0)	1.11 (1.01– 1.22)	0.04*	0.98 (0.75 – 1.21)	0.85
Constipation	11.3 (21.9)	1.18 (1.07 – 1.28)	0.001*	1.12 (0.96 – 1.27)	0.13
Diarrhea	8.5 (18.6)	0.98 (0.82 – 1.15)	0.85	1.02 (0.85 – 1.20)	0.79
Financial	21.4 (30.2)	1.04 (0.95 – 1.14)	0.36	0.91 (0.74 – 1.08)	0.27

• HRs correspond to a 10-point increment for QoL scores.
• 2 sets of multivariate models were constructed: one for global QoL and other for all general function and symptom variables combined.
• Multivariate model (for general function and symptom variables combined) adjusted for prior treatment history, stage at diagnosis and all baseline QoL variables.
• Multivariate model for global QoL adjusted for prior treatment history and stage at diagnosis.
*P < 0.05.

ISSN: 1471-2490