Figure 2

Time course response of frequency of the bladder rhythmic contraction to unilateral and bilateral spinal nerve stimulation (10 Hz, pulse width 0.1 ms) at motor threshold intensity (A), a supra-threshold intensity of 0.6 mA (B) or bilateral 10 Hz neuromodulation in pulse matched or pulse mismatched fashion (C). Schematic drawings of the stimulation waveform of pulse match and pulse mismatch are shown in C. There is no delay or a 50-ms delay between right and left pulses in pulse match or pulse mismatch, respectively. Responses are represented as a percentage of pretreatment values (% control), where the baseline response before stimulation is defined as 100%. * p < 0.05, vs control without stimulation; repeated measures ANOVA, Bonferroni post test. Shaded areas are responses during electrical stimulation.