Quantification of effectiveness of bilateral and unilateral neuromodulation in the rat bladder rhythmic contraction model

Table 1 Contraction frequency (contractions per min) to spinal nerve Stimulation

	Before	Treatment	10 min post	20 min post
without stimulation	0.64 ± 0.06	0.62 ± 0.05	0.63 ± 0.07	0.65 ± 0.07
10 Hz, T_mot, unilateral	0.58 ± 0.05	0.51 ± 0.07	0.63 ± 0.07	0.62 ± 0.08
sequential 10 min	0.67 ± 0.04	0.50 ± 0.11	0.60 ± 0.12	0.64 ± 0.11
sequential 20 min	0.55 ± 0.05	0.38 ± 0.10 * +	0.53 ± 0.07	0.56 ± 0.07
10 Hz, T_mot, bilateral	0.63 ± 0.04	0.17 ± 0.09 * + #	0.37 ± 0.09 * + #	0.66 ± 0.14
0.5 Hz, 0.6 mA, unilateral	0.57 ± 0.09	0.30 ± 0.09 * +	0.47 ± 0.10	0.53 ± 0.10
0.5 Hz, 0.6 mA, bilateral	0.85 ± 0.06	0.20 ± 0.08 * +	0.50 ± 0.08	0.60 ± 0.15
10 Hz, 0.6 mA, unilateral	0.75 ± 0.06	0 ± 0 * +	0.43 ± 0.09	0.66 ± 0.06
10 Hz, 0.6 mA, bilateral	0.72 ± 0.10	0 ± 0 * +	0.20 ± 0.07 * +	0.49 ± 0.15
0.8 × T_mot, pulse match	0.47 ± 0.03	0.32 ± 0.05	0.36 ± 0.04 +	0.37 ± 0.06 +
0.8 × T_mot, pulse mismatch	0.56 ± 0.06	0.38 ± 0.07 +	0.36 ± 0.07	0.29 ± 0.06 +
1 × T_mot, pulse match	0.42 ± 0.04	0.14 ± 0.06 * +	0.26 ± 0.06 +	0.30 ± 0.07 +
1 × T_mot, pulse mismatch	0.54 ± 0.10	0.09 ± 0.05 * +	0.22 ± 0.05 +	0.23 ± 0.03 +

* P < 0.05, paired student’s t test for intragroup comparison to “before treatment”.
+ P < 0.05, unpaired student’s t test for intergroup comparison to “without stimulation”.
# P < 0.05, unpaired student’s t test for intergroup comparison to “unilateral stimulation”.

ISSN: 1471-2490