Table 1 Patient characteristics
Renal vein | IVC thrombus | ||||||
|---|---|---|---|---|---|---|---|
All | Surgery performed | Surgery not performed | P value | Surgery performed | Surgery not performed | P value | |
n | 85 | 35 | 7 | 30 | 13 | ||
Age* | 62 ± 12 | 63 ± 10 | 62 ± 10 | 0.790 | 59 ± 14 | 37 ± 11 | 0.078 |
Gender | 24/11 | 4/3 | 0.558 | 17/13 | 10/3 | 0.021 | |
ECOG-PS | 0.6 ± 1.1 | 0.3 ± 0.7 | 0.7 ± 1.5 | 0.484 | 0.5 ± 1.0 | 1.6 ± 1.4 | 0.021 |
Radical surgery | 65(76%) | 35 | 0 | 30 | 0 | ||
Perioperative morality within 1 month | 0(0%) | 2(7%) | |||||
Thrombus level | |||||||
Renal vein | 42(49%) | 35 | 7 | ||||
I | 11(13%) | 7(23%) | 4(31%) | 0.203 | |||
II | 15(18%) | 13(43%) | 2(15%) | ||||
III | 12(14%) | 8(27%) | 4(31%) | ||||
IV | 5(6%) | 2(7%) | 3(23%) | ||||
Clinical TNM | |||||||
cT3 | 78(92%) | 35(100%) | 6(86%) | 0.024 | 30(100%) | 7(54%) | 0.000 |
cT4 | 7(8%) | 0(0%) | 1(14%) | 0(0%) | 6(46%) | ||
cN+ | 20(24%) | 1(3%) | 5(71%) | <0.0001 | 5(17%) | 9(69%) | 0.001 |
cM+ | 45(53%) | 11(31%) | 6(86%) | 0.008 | 17(33%) | 11(85%) | 0.041 |
Multiple organ metastasis | 19(22%) | 2(6%) | 4(57%) | 0.006 | 5(17%) | 8(62%) | 0.041 |
Thrombus level (I/II/III/IV) | 1/2/2/0 | 2/2/2/2 | |||||
Histology | |||||||
Clear | 67(79%) | 31(89%) | 5(71%) | 0.426 | 27(93%) | 4(31%) | 0.508 |
Others | 7(8%) | 4(11%) | 0(0%) | 3(7%) | 0(0%) | ||
Unknown | 11(13%) | 0(0%) | 2(29%) | 0(0%) | 9(96%) | ||
Grade | |||||||
G1/2 | 43(51%) | 25(71%) | 0(0%) | 0.002 | 12(40%) | 4(31%) | 0.024 |
G3 | 31(36%) | 10(29%) | 5(71%) | 12(40%) | 4(31%) | ||
Unknown | 11(13%) | 0(0%) | 2(29%) | 0(0%) | 9(69%) | ||
Hemoglobin (g/dl)* | 11.6 ± 2.4 | 12.0 ± 2.2 | 104 ± 2.0 | 0.081 | 11.4 ± 2.3 | 11.2 ± 3.3 | 0.752 |
Neutrophil-lymphocyte ratio* | 3.1 ± 1.5 | 2.8 ± 1.2 | 3.6 ± 1.2 | 0.156 | 3.1 ± 1.9 | 3.6 ± 1.5 | 0.402 |
Serum albumin (g/dl)* | 3.8 ± 0.6 | 3.9 ± 0.6 | 3.4 ± 0.8 | 0.122 | 3.9 ± 0.6 | 3.5 ± 1.5 | 0.080 |
Renal function (ml/min./1.73 m2)* | 63 ± 23 | 71 ± 20 | 52 ± 21 | 0.063 | 60 ± 23 | 56 ± 25 | 0.605 |
Lactate dehydrogenase (LDH,|IU/L)* | 214 ± 112 | 185 ± 45 | 304 ± 217 | 0.198 | 199 ± 80 | 274 ± 172 | 0.154 |
Choline esterase (U/L)* | 224 ± 105 | 248 ± 98 | 234 ± 72 | 0.665 | 215 ± 130 | 172 ± 102 | 0.252 |
Serum sodium (mEq/L)* | 141 ± 2.5 | 142 ± 2.3 | 139 ± 3.7 | 0.111 | 142 ± 2.2 | 139 ± 2.3 | 0.005 |
Correlated calcium (mg/dL)* | 9.6 ± 0.8 | 9.4 ± 0.6 | 9.9 ± 0.8 | 0.153 | 9.6 ± 0.8 | 10.1 ± 0.8 | 0.069 |
C-reactive protein (CRP, mg/dL)* | 4.4 ± 5.4 | 4.1 ± 6.1 | 4.8 ± 3.3 | 0.648 | 3.7 ± 6.0 | 6.4 ± 4.6 | 0.125 |
Charlson comorbidity index* | 7.7 ± 3.4 | 6.6 ± 3.1 | 11.3 ± 1.6 | <0.0001 | 7.2 ± 3.1 | 10.3 ± 3.0 | 0.004 |
Molecular targeted agents | 18(21%) | 5(14%) | 4(57%) | 0.012 | 6(20%) | 3(23%) | 0.549 |
Deceased | 43(51%) | 8(23%) | 4(57%) | 0.067 | 20(67%) | 11(85%) | 0.228 |