Disease-specific outcomes of Radical Prostatectomies in Northern Norway; a case for the impact of perineural infiltration and postoperative PSA-doubling time

Table 1 Patient characteristics and clinicopathological variables, and their prognostic value for the three endpoints in 535 prostate cancer patients (univariate analyses; log rank test)

Characteristic	Patients	Patients	BF		CF		PCD
	(n)	(%)	(170 events)		(36 events)		(15 events)
			5-year EFS (%)	p	10-year EFS (%)	p	10-year EFS (%)	p
Age				0.55		0.085		0.600
≤ 65 years	357	67	76		92		97
> 65 years	178	33	70		88		96
pT-stage				<0.001		<0.001		0.027
pT2	374	70	83		96		98
pT3a	114	21	60		86		98
pT3b	47	9	43		73		89
pN-stage				<0.001		<0.001		<0.001
NX	264	49	79		95		98
N0	268	50	71		89		97
N1	3	1	0		33		67
Preop PSA				<0.001		0.085		0.061
PSA < 10	308	57	80		93		99
PSA > 10	221	42	67		88		95
Missing	6	1	-		-		-
Gleason				<0.001		<0.001		0.001
3 + 3	183	34	83		98		99
3 + 4	220	41	76		93		98
4 + 3	80	15	69		84		95
4 + 4	19	4	63		76		94
≥9	33	6	34		67		87
Tumor size				<0.001		0.019		0.098
0-20 mm	250	47	82		94		99
>20 mm	285	53	67		88		96
PNI				<0.001		<0.001		0.002
No	401	75	79		95		98
Yes	134	25	60		81		93
PSM				0.041		0.038		0.697
No	249	47	81		94		97
Yes	286	53	69		89		97
Non-apical PSM				<0.001		<0.001		0.029
No	381	71	81		95		98
Yes	154	29	57		81		94
Apical PSM				0.04		0.484		0.31
No	325	61	73		90		96
Yes	210	39	77		92		98
LVI				<0.001		<0.001		0.009
No	492	92	77		93		98
Yes	43	8	46		71		88
Surgical proc				0.23		0.41		0.581
Retropubic	435	81	76		90		97
Perineal	100	19	67		95		98

Abbreviations: BF biochemical failure, CF Clinical failure, EFS event free survival in months, LVI lymphovascular infiltration, PCD prostate cancer death, NR not reached, P P value for log rank statistic for difference in event free survival, PC Prostate cancer, PNI Perineural infiltration, Post op RT postoperative radiotherapy, Preop preoperative, PSA Prostate specific antigen, PSM Positive surgical margin, Surgical proc surgical procedure. Significant p-values in bold (threshold p ≤ 0.05).

ISSN: 1471-2490