Figure 2

Antihistamines specific for H2 receptor attenuate pelvic pain. A) Female mice treated by oral gavage with saline exhibited significantly increased pelvic sensitivity relative to baseline at PID 2, 3 and 4 for all filaments tested (n = 8, P < 0.05). B) Female mice treated by oral gavage with the H2R antagonist cimetidine showed reduced pelvic sensitivity that was not significantly increased above baseline until PID 4 (n = 10, P < 0.05). C) Female mice treated by oral gavage with H2R antagonist ranitidine did not develop significant pelvic sensitivity (n = 10). D) Female mice treated by oral gavage with the H2R antagonist famotidine showed reduced pelvic sensitivity that was not significantly increased above baseline until PID 4 (n = 10, P < 0.05). The symbol key shown in (A) applies to panels A-D. Error bars depict SEM, and significance was determined by ANOVA.