Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study

BMC Urology

Table 2 Association between plasma fluorescent oxidation products (FlOPs) and erectile dysfunction in prostate cancer cases (N =457) and controls (N = 460): prospective analysis in the Health Professional Follow-up Study, 1993-2001

Tertile	1	2	3	P for trend
Variables	FlOP_360			P for trend
Range (FI/ml)	< 184	≥ 184; < 233	≥ 233	---
N	305	306	306	---
Median (FI/ml)	160	207	280	---
Erectile dysfunction incidence (n, %)	100 (33 %)	112 (37 %)	111 (36 %)	---
Age adjusted	1 (ref)	1.13 (0.79, 1.61)	1.07 (0.75, 1.52)	0.84
Multivariable adjusted^a	1 (ref)	1.03 (0.71, 1.51)	0.90 (0.61, 1.34)	0.54
	FlOP_320
Range (FI/ml)	< 356	≥ 356; < 524	≥ 524	---
N	305	306	306	---
Median (FI/ml)	302	410	1837	---
Erectile dysfunction incidence (n, %)	102 (33 %)	114 (37 %)	107 (35 %)	---
Age adjusted	1 (ref)	1.00 (0.70, 1.42)	0.86 (0.60, 1.23)	0.30
Multivariable adjusted^a	1 (ref)	0.75 (0.51, 1.11)	0.73 (0.49, 1.07)	0.27
	FlOP_400
Range (FI/ml)	< 49.1	≥ 49.1; < 62.6	≥ 62.6	---
N	305	306	306	---
Median (FI/ml)	44.0	55.1	72.6	---
Erectile dysfunction incidence (n, %)	100 (33 %)	99 (32 %)	124 (41 %)	---
Age adjusted	1 (ref)	0.82 (0.57, 1.17)	1.24 (0.87, 1.77)	0.14
Multivariable adjusted^a	1 (ref)	0.67 (0.45, 0.99)	0.98 (0.66, 1.45)	0.72

Values are odds ratio (95 % confidence interval), unless otherwise specified. FI = Fluorescent intensity units
^aRisk factors include age (continuous), body mass index (continuous), alcohol intake (in quartiles: < 0.88, ≥ 0.88 and < 5.58, ≥ 5.58 and < 16.38, ≥ 16.38 g/day), physical activity (in quartiles: < 15.6, ≥ 15.6and < 30.6, ≥ 30.6 and < 56.9, ≥ 56.9 MET-hours/week), Caucasian (yes/no), fasting hours (continuous), benign prostatic hyperplasia with surgery (yes/no), history of hypertension (yes/no), history of diabetes (yes/no), smoking status (current smokers, past smokers and non-smokers), month of blood draw (in seasons: Spring [March, April and May], Summer [June, July and August], Fall [September, October and November], Winter [December, January and February]) and year of blood draw (1993, 1994 and 1995)

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