Table 2 Impact of patient characteristics and comorbidities on the continuation of treatment with tadalafil 5 mg OaD (N = 778)
Population | Number of patients with | Patients without events (%), KM estimate [95 % CI] | |||
|---|---|---|---|---|---|
Data | Events | Month 2 | Month 4 | Month 6 | |
Overall (primary analysis) | 773 | 107 | 94.0 [92.3,95.7] | 88.3 [85.9,90.6] | 86.3 [83.7,88.9] |
By age | |||||
Age ≤65 years | 593 | 61 | 96.2 [94.7,97.8] | 91.7 [89.4,93.9] | 89.8 [87.1,92.4] |
Age >65 years | 180 | 46 | 86.7 [81.7,91.6] | 77.3 [71.1,83.5] | 75.0 [68.5, 81.5] |
By PDE5-I treatment | |||||
PDE5-I naïve | 507 | 71 | 93.9 [91.8,96.0] | 88.5 [85.7,91.4] | 86.1 [82.9,89.4] |
PDE5-I pretreated | 265 | 36 | 94.2 [91.4,97.1] | 87.6 [83.6,91.7] | 86.6 [82.3,90.9] |
By disease severity | |||||
Mild ED | 160 | 16 | 98.1 [96.0,1.00] | 94.1 [90.3,97.8] | 89.8 [84.4,95.3] |
Moderate ED | 407 | 55 | 94.8 [92.7,97.0] | 88.6 [85.5,91.8] | 87.3 [83.9,90.8] |
Severe ED | 203 | 36 | 89.0 [84.6,93.3] | 82.8 [77.4,88.2] | 80.8 [75.1,86.5] |
By presence of BPH | |||||
BPH present | 49 | 10 | 91.8 [84.2,99.5] | 87.8 [78.6,96.9] | 84.9 [74.5,95.3] |
BPH absent | 724 | 97 | 94.1 [92.4,95.9] | 88.3 [85.9,90.7] | 86.4 [83.7,89.1] |
By presence of diabetes | |||||
Diabetes present | 123 | 19 | 93.4 [88.9,97.8] | 85.3 [78.9,91.8] | 84.0 [77.2,90.9] |
Diabetes absent | 650 | 88 | 94.1 [92.3,95.9] | 88.8 [86.3,91.3] | 86.7 [83.9, 89.5] |
By presence of CVD | |||||
CVD present | 266 | 41 | 90.9 [87.4,94.4] | 86.8 [82.7,91.0] | 84.6 [80.1,89.2] |
CVD absent | 507 | 66 | 95.6 [93.8,97.4] | 89.0 [86.2,91.8] | 87.2 [84.0,90.3] |
By presence of hypertension | |||||
Hypertension present | 258 | 40 | 91.0 [87.5,94.5] | 86.8 [82.6,91.0] | 84.6 [79.9,89.2] |
Hypertension absent | 515 | 67 | 95.5 [93.7,97.3] | 89.0 [86.2,91.8] | 87.2 [84.0,90.3] |
By presence of dyslipidemia | |||||
Dyslipidemia present | 144 | 24 | 91.6 [87.0,96.1] | 86.3 [80.6,92.1] | 83.5 [77.2,89.9] |
Dyslipidemia absent | 629 | 83 | 94.5 [92.8,96.3] | 88.7 [86.2,91.2] | 87.0 [84.2,89.8] |