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Table 1 Prostate cancers analyzed for mismatch-repair function

From: Frequent mismatch-repair defects link prostate cancer to Lynch syndrome

ID no. Status Age at diagnosis Gleason score TILs ≥4/HPF MMR gene mutation Immunohistochemical staining MSI
MLH1 PMS2 MSH2 MSH6
P32 Carrier 56 9 (4 + 5) NA MSH2 c.(?_-68)_366 + ?del    NA   
P7 Carrier 53 8 (4 + 4) y MSH2 c.560G > T + + MSI-L
P14 FDR 63 9 (5 + 4) y MSH2 c.646-?_1276 + ?del + + MSI-L
P8 Carrier 69 9 (4 + 5) y MSH2 c.892C > T + + MSI-L
P33 FDR 77 NA NA MSH2 c. 942 + 3A > T    NA   
P34 FDR 62 NA NA MSH2 c. 942 + 3A > T    NA   
P5 Carrier 69 8 (3 + 5) NA MSH2 c. 942 + 3A > T    NA   
P31 FDR 56 10 (5 + 5) NA MSH2 c. 942 + 3A > T    NA   
P10 Carrier 76 7 (4 + 3) y MSH2 c.1786_788delAAT + + MSI-L
P20 FDR 81 10 (5 + 5) y MSH2 c.1786_788delAAT + + MSI-H
P9 Carrier 52 8 (4 + 4) y MSH2 c.1906G > C + + MSS
P30 Carrier 60 NA NA MSH2 c.2038C > T    NA   
P12 Carrier 57 6 (3 + 3) y MSH2 c.2347delC + + MSI-H
P35 Carrier 67 NA NA MLH1 c. 350C > T    NA   
P11 Carrie 63 7 (4 + 3) n MLH1 c.588 + 5G > A + + + + MSS
P22 FDR 56 7 (3 + 4) y MLH1 c.1537_1547delInsC + + MSS
P2 Carrier 60 8 (4 + 4) n MLH1 c.1667 + 2delTAAATCAinsATTT + + + + MSS
P13 FDR 63 9 (4 + 5) y MLH1 c.1667 + 2delTAAATCAinsATTT + + MSI-L
P18 FDR 63 7 (3 + 4) y MLH1 c.1667 + 2delTAAATCAinsATTT + + + + MSS
P6 FDR 80 7 (3 + 4) n MLH1 c.1732-2A > T + + + + MSS
P1 Carrier 72 NA NA MLH1 c.1732-2A > T    NA   
P16 Carrier 74 10 (5 + 5) n MLH1 c.1852_54delAAG + + + + MSS
P37 Carrier 58 NA NA MSH6 C.1444C > T    NA   
P3 Carrier 58 8 (4 + 4) y MSH6 c.1483C > T + + MSI-L
P15 Carrier 78 6 (3 + 3) y MSH6 c.3647-1G > A + + + MSS
P38 FDR 81 NA NA MSH6 c. 3609_3612delTGCA    NA   
P36 FDR 53 NA NA MSH6 c.3992 + 1 T > C    NA   
P17 FDR 57 7 (3 + 4) NA MSH6 c.3992 + 1 T > C    NA   
  1. Abbreviations: FDR first-degree relatives, HPF high-power field, MMR mismatch repair, MSI microsatellite instability high/low, MSS microsatellite stability, n no, TIL tumour-infiltrating lymphocytes, y yes, NA Not available