Table 1 Summary of all pre-clinical studies
Author, year [reference] | Study type | Model | Compound used | Main study finding |
|---|---|---|---|---|
Habib FK, 1990 [18] | In vitro study | Human prostate cancer cell line | pollen extract | - pollen extract is able to inhibit the prostate cancer cell growth (hormone-independent model) |
Habib FK, 1995 [19] | In vitro study | Human prostate cancer cell line (DU145) | pollen extract | - pollen extract V-7 fraction is able to inhibit the prostate cancer cell growth |
Kamijo T, 2001 [12] | Animal model | Rats | pollen extract | - pollen extract protects acinar epithelial cells and inhibits stromal proliferation in association with enhanced apoptosis |
Loschen G, 1991 [20] | In vitro study | Microsomes (RBL-1 cells) | pollen extract | - pollen extract shows an anti-inflammatory and anti-proliferative therapeutic effect |
Talpur N, 2003 [21] | Animal model | Rats | pollen extract vs serenoa repens | - pollen extract is able to influence prostatic hyperplasia via effects on androgen metabolism |
Nagashima A, 1998 [22] | Animal model | Rats | pollen extract | - pollen extract increases the maximum pressure during urination to promote the urination reflex |