Fig. 1From: Assessment of free-hand transperineal targeted prostate biopsy using multiparametric magnetic resonance imaging-transrectal ultrasound fusion in Chinese men with prior negative biopsy and elevated prostate-specific antigenSteps for mpMRI and TRUS fusion guided targeted prostate biopsy and whole-gland prostatectomy pathology in a typical patient with negative biopsy two years ago but elevated prostate-specific antigen. A-C, The lesion (red arrow) was detected in different mpMRI sequences and was scored as āprobably malignantā (score 4 of 5). D-E, mpMRI data was loaded into the biopsy system and suspicious region (greeb circle) was marked on high resolution transversal T2Ā W sequences before biopsy. Then, the targeted biopsy started using the free-hand transperineal technique guided by mpMRI and TRUS fusion images (red arrow). F, Targeted cores revealed Gleason 3Ā +Ā 4 tumor in the lesion (90% core involvement). Whole-gland pathology was performed after prostatectomy and the index lesion (black circle) had the same pathology result with targeted biopsyBack to article page