Table 1 Patient & disease characteristics overall, stratified by surgical margin status
Variable | Patients with positive margins | Patients with negative margins | Overall | p value |
|---|---|---|---|---|
N (%) | 181 (30.6) | 411 (69.4) | 592 | |
Patient age at time of surgery | ||||
Under 65 years | 82 (45.3) | 252 (61.3) | 334 (56.4) | 0.009 |
65 years and above | 99 (54.7) | 159 (38.7) | 258 (43.6) | |
Pre-op PSA | ||||
0.0-9.9 | 103 (57.9) | 276 (68.3) | 379 (65.1) | 0.03 |
10.0-19.9 | 58 (32.6) | 110 (27.2) | 168 (28.9) | |
20.0 and above | 17 (9.6) | 19 (4.5) | 35 (6.0) | |
Missing | 2 | 7 | 9 | |
Gleason score on biopsy | ||||
Group 1 (GS 2-6) | 81 (44.8) | 191 (46.5) | 272 (46.0) | 0.5 |
Group 2 (GS 3+4) | 74 (40.9) | 165 (40.2) | 239 (40.4) | |
Group 3 (GS 4+3) | 20 (11.0) | 35 (8.5) | 55 (9.3) | |
Group 4 (GS 8) | 3 (1.7) | 16 (3.9) | 19 (3.2) | |
Group 5 (GS 9-10) | 3 (1.7) | 4 (1.0) | 7 (1.2) | |
Pathological Gleason score | ||||
Group 1 (GS 2-6) | 26 (14.4) | 117 (28.5) | 143 (24.2) | <0.001 |
Group 2 (GS 3+4) | 92 (50.8) | 218 (54.0) | 310 (52.4) | |
Group 3 (GS 4+3) | 33 (18.2) | 40 (9.7) | 73 (12.3) | |
Group 4 (GS 8) | 20 (11.1) | 31 (7.5) | 51 (8.6) | |
Group 5 (GS 9-10) | 10 (5.5) | 5 (1.2) | 15 (2.5) | |
Pathological tumour stage | ||||
pT2 | 89 (49.2) | 318 (77.4) | 407 (68.8) | <0.001 |
pT3a | 68 (37.6) | 81 (19.7) | 149 (25.2) | |
pT3b | 24 (13.3) | 12 (2.9) | 36 (6.1) | |
Lymph node involvement | 10 (11.8) | 7 (4.6) | 17 (7.2) | 0.06 |
Tumour volume of excised specimen | ||||
Median (IQR) | 3.9 (1.8-6.7) | 2.02 (0.81-4.0) | 2.4 (1.0-5.1) | <0.001 |
Surgical approach | ||||
LRP | 109 (60.2) | 284 (69.1) | 393 (66.4) | 0.05 |
RARP | 72 (39.8) | 157 (30.9) | 199 (33.6) | |
Post-operative PSA* | ||||
Biochemical recurrence (%) | 15/140 (10.7) | 18 of 350 (5.1) | 33 of 490 (6.7) | 0.045 |
Median time to BCR (in months, IQR)* | 10.9 (3.7-24.5) | 13.1 (4.9-37.7) | 12.1 (4.9-31.4) | 0.5 |