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Table 2 Gene expression and prognostic factors of ccRCC

From: Expression of micro-RNAs and genes related to angiogenesis in ccRCC and associations with tumor characteristics

 

mTOR

VEGFR1

VEGFR2

VEGFA

HIF1A

PDGF

VHL

Low (n = 18)

0.63(1.32)

1.96(2.10)

3.17(6.12)

11.87 (16.14)

1.56 (2.27)

5.91 (11.18)

0.29 (1.04)

Intermediate (n = 29)

1.32 (5.43)

1.84(4.85)

1.11(1.38)

7.10 (4.47)

1.05 (1.29)

4.27 (9.39)

18.28 (87.65)

High n = 9

0.55 (0.63)

4.48(6.10)

1.51(2.26)

4.20 (4.58)

3.12 (5.58)

7.05 (9.53)

5.18 (6.73)

p

0.82b

0.37b

0.89b

0.18b

0.43b

0.76b

0.67b

Size ≥7 cm (n = 30)

0.52 (1.11)

1.74 (2.06)

2.41 (5.14)

10.33 (13,53)

1.27 (1.97)

6.62 (12.76)

0.39 (1.20)

Size <7 cm (n = 26)

1.54 (5.84)

2.69 (5.81)

1.31 (1.72)

6.32 (4.45)

1.74 (3.10)

3.56 (5.17)

18.84 (85.70)

p

0.97a

0.59a

0.87a

0.17a

0.50a

0.97a

0.12a

MVI absent (n = 44)

0.45 (0.95)

2.03(4.11)

2.08 (4.27)

9.77 (11.28)

1.10(1.63)

5.24(10.57)

12.54(72.60)

MVI present (n = 12)

3.39 (9.18)

2.75(4.76)

1.10 (1.71)

3.61(3.57)

2.91(4.36)

4.89(7.41)

3.66(5.73)

p

0.25a

0.61a

0.46a

0.57a

0.08a

0.91a

0.68a

Fuhrman’s Grade I e II (n = 32)

1.43 (5.32)

1.57 (1.79)

2.43 (4.97)

9.86 (13.09)

1.54 (2.11)

4.39 (9.21)

0.19 (0.84)

Fuhrman’s Grade III e IV (n = 24)

0.40 (0.52)

3.00 (6.10)

1.19 (1.68)

6.57 (4.81)

1.45 (3.06)

6.17 (10.97)

20.65 (89.28)

p

0.81a

0.45a

0.56a

0.26a

0.89a

0.51a

0.13a

Metastasis Absent (n = 48)

0.46(0.93)

1.81 (2.86)

1.96 (4.14)

8.53 (11.20)

1.54(2.76)

5.59 (10.78)

1.18 (3.44)

Metastasis Present (n = 8)

3.64(9.71)

4.03 (8.24)

1.41 (2.10)

7.98(4.54)

1.27(1.20)

3.05(3.04)

54.33(151.70)

p

0.82a

0.49a

0.71a

0.89a

0.77a

0.49a

0.79a

pT1–2 (n = 26)

0.51 (1.16)

1.33 (1.74)

2.47 (5.31)

10.12 (14.05)

1.47 (2.13)

7.07 (13.16)

0.20 (0.86)

pT3–4 (n = 30)

1.48 (5.62)

3.03 (5.63)

1.33 (1.72)

6.83 (4.67)

1.53 (2.95)

3.34 (4.95)

19.00 (85.67)

p

0.38a

0.51a

0.97a

0.26a

0.80a

0.16a

0.18a

  1. aMann-Whitney test b Kruskall-Wallis Test