Skip to main content

Table 2 Characteristics of the included studies on PNI in patients with PCa following RT

From: Perineural invasion as an independent predictor of biochemical recurrence in prostate cancer following radical prostatectomy or radiotherapy: a systematic review and meta-analysis

Author

Year

Country

Recruitment period

sample size

Age (years)

p-PSA (ng/ml)

GS≥7 (n.%)

PNI (n.%)

Radiotherapy

Follow-up (months)

NOS (score)

Copp et al[39]

2005

USA

1997-2000

93

Median 69.1

Median 9.1

34(36.6%)

17(18.3%)

EBRT

Median 45

7

Yu et al[19]

2007

USA

1993-2002

657

Mean 68

NR

238(36.2%)

112 (19.1%)

EBRT

Median 68

7

Pina et al[40]

2010

Canada

1999-2008

339

Mean 61.9

Mean 5.7

45(13.3%)

89(26.3%)

BT

Median 32

8

Feng et al[41]

2011

USA

1998-2008

718

Median 69.4

Median 8.3

474(66%)

220(34%)

EBRT

Median 62.2

8

Ding et al[30]

2012

USA

1998-2003

185

Median 69

NR

47(25.4%)

10(5%)

BT/ EBRT

Median 80

7

Spratt et al[42]

2013

USA

1989-2011

613

Median 70

NR

613(100%)

156(25.4%)

EBRT

Median 72

7

  1. GS: Gleason score; PNI: perineural invasion; EBRT: external beam radiotherapy; BT: brachytherapy; NR: not reported; NOS: Newcastle–Ottawa Scale; p-PSA: preoperative PSA