Fig. 1

Rapid generation of a transcript test set using 3 web-based tools: CRN, cBioPortal, and camcAPP. a) Outline of steps used to generate the transcript test set. b) cBioPortal oncoprint (step 2) example (MELK) indicates 36% of patients with Gleason score 7 tumours who experienced biochemical recurrence (BCR) had increased MELK transcript. In contrast, only 7% of those who remained BCR-free had increased transcript. Patients (individual bars) are aligned within the three rows. nc- no difference in tumour transcript abundance compared with normal tissue. c) camcAPP Kaplan-Meier plots (step 3) example (MELK) shows higher MELK expression is associated with shorter time to BCR in all three datasets. Grouping of samples determined by recursive partitioning (Hothorn et al., 2006). b, c) MSKCC data from Taylor et al., 2010. c) Cambridge and Stockholm data from Ross-Adams et al., 2015