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Table 1 Summary statistics on DNA Damage Response pathway alterations in clinically localized prostate cancer

From: Similar incidence of DNA damage response pathway alterations between clinically localized and metastatic prostate cancer

Parameters Normal (unaffected) Mutated (affected) p-value
Total sample size, N 319 136  
Age (years), median (range) 61 (41–77) 62 (43–78) 0.034
PSA pre-operative, median (ng/ml), (range), n 6.8 (2.2–56.4), 125 9.7 (2.2–87.0), 39 Not significant
Stage, pathologic American Joint Committee on Cancer Tumor Stage Code, N (%)    Not significant
 pT2 127 (39.8) 47 (34.6)  
 pT3 186 (58.3) 86 (63.2)  
 pT4 6 (1.9) 3 (2.2)  
Gleason score, pathologic, N (%)    Not significant
 6 28 (8.8) 9 (6.6)  
 7 163 (51.1) 67 (49.3)  
 8–10 128 (40.1) 60 (44.1)