Fig. 2

Comparison of morphological phenotypes and spatial distribution of TREK-1 channel in visceral organs of WT and TREK-1 KO mice. Representative images of immunohistochemically labeled TREK-1 protein in paraffin sections obtained from WT (left panels, N = 4, n = 20) and TREK-1 KO (right panels, N = 4, n = 20) mice. a) Colon, b) Urinary bladder, c) Kidneys. Used abbreviations: m-mucosa; cm-circular muscle; lm-longitudinal muscle; sm-smooth muscle; rc-renal corpuscle; cd-collecting ducts; bc-Bowman’s capsule. The scale bar is 50 μm. d Trichrome staining of urinary bladder cross-sections from WT and TREK-1 KO mice (10x). E) Body/bladder weight ratio in WT and TREK-1 KO animals