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Table 4 Mutually adjusted logistic regression analysis for pathological upgrading after RP

From: Pathological upgrading in prostate cancer treated with surgery in the United Kingdom: trends and risk factors from the British Association of Urological Surgeons Radical Prostatectomy Registry

Characteristic

Odds ratio (95% confidence interval)

p-value

Age

1.022 (1.016–1.028)

< 0.001

Preoperative PSA

1.026 (1.022–1.031)

< 0.001

Preoperative biopsy ISUP Grade Group

 1 (reference)

1

 

 2

0.123 (0.112–0.135)

< 0.001

 3

0.057 (0.049–0.065)

< 0.001

 4

0.085 (0.072–0.101)

< 0.001

 5

0.030 (0.023–0.039)

< 0.001

Preoperative clinical stage

 T1 (reference)

1

 

 T2

1.231 (1.120–1.353)

< 0.001

 T3

1.990 (1.774–2.232)

< 0.001

 T4

1.199 (0.275–5.237)

0.809

Year of surgery

 2011 (reference)

1

 

 2012

0.930 (0.749–1.156)

0.514

 2013

1.084 (0.896–1.311)

0.408

 2014

0.851 (0.710–1.021)

0.082

 2015

0.935 (0.782–1.118)

0.462

 2016

0.908 (0.759–1.086)

0.289

Region

 A

0.792 (0.403–1.556)

0.498

 B

1.077 (0.857–1.353)

0.526

 C

1.071 (0.906–1.265)

0.421

 D

0.980 (0.834–1.152)

0.808

 E

0.886 (0.704–1.115)

0.303

 F

1.152 (0.984–1.348)

0.078

 G

0.891 (0.743–1.068)

0.210

 H

1.980 (0.840–4.669)

0.118

 I

1.299 (0.688–2.452)

0.420

 J (reference)a

1

 

 K

0.830 (0.706–0.976)

0.024

 L

0.863 (0.731–1.020)

0.084

 M

0.837 (0.678–1.033)

0.098

 N

1.132 (0.963–1.330)

0.133

 O

0.995 (0.741–1.338)

0.976

 P

0.654 (0.477–0.897)

0.008

  1. aRegion J chosen as a reference owing to largest number of patients