Table 6 Summary of Aging male symptoms (AMS) subscale analysis

Visit

Intervention

(VISPO)

n = 33

Comparator

(SPO)

n = 33

Placebo

n = 33

p-value**

Intervention

(VISPO)

n = 33

p-value*

Comparator

(SPO)

n = 33

p-value*

Placebo

n = 33

p-value*

p-value**

Visit 1

12.64 ± 4.08

12.97 ± 3.58

13.79 ± 4.92

0.559²⁾

Visit 2

12.58 ± 3.75

12.82 ± 3.40

13.79 ± 4.72

0.510²⁾

− 0.06 ± 0.75

0.645

− 0.15 ± 0.83

0.304

0.00 ± 0.50

1.000

0.683¹⁾

Visit 3

12.58 ± 3.67

12.73 ± 3.31

14.06 ± 4.39

0.351²⁾

− 0.06 ± 1.00

0.730

−0.24 ± 1.25

0.274

0.27 ± 1.04

0.141

0.162¹⁾

Visit 1

19.27 ± 3.88

19.85 ± 4.43

20.67 ± 4.26

0.403¹⁾

Visit 2

18.39 ± 3.64

19.45 ± 4.37^ab

20.85 ± 3.97^b

0.049¹⁾

−0.88 ± 1.14^a

< 0.001

− 0.39 ± 0.90^a

0.017

0.18 ± 0.58^b

.083

< 0.001²⁾

Visit 3

16.97 ± 3.10^a

19.12 ± 4.52^ab

20.79 ± 3.90^b

0.001²⁾

−2.30 ± 2.65^a

< 0.001

−0.73 ± 2.30^b

0.078

0.12 ± 2.06^b

.737

< 0.001¹⁾

Visit 1

13.15 ± 3.28^a

11.82 ± 2.48^ab

10.97 ± 2.89^b

0.011¹⁾

Visit 2

12.55 ± 3.10

11.70 ± 2.64

11.42 ± 2.69

0.247¹⁾

−0.61 ± 0.97^a

0.001

−0.12 ± 0.82^ab

0.402

0.45 ± 1.06^b

.020

< 0.001¹⁾

Visit 3

11.91 ± 2.96

11.70 ± 2.48

11.70 ± 2.65

0.935¹⁾

−1.24 ± 1.84^a

<.001

−0.12 ± 1.47^b

0.640

0.73 ± 1.26^C

.002

< 0.001²⁾