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Fig. 1 | BMC Urology

Fig. 1

From: Hyperpolarization-activated cation currents in medium-size dorsal root ganglion cells are involved in overactive bladder syndrome in rats

Fig. 1

Effects of ZD288 on the AP amplitude, half-width, threshold value, and after hyperpolarization amplitude of the medium-size DRG neurons in OAB and sham-intervention rats. The amplitude, half-width, afterhyperpolarization potential (AHP) amplitude and threshold value of the first induced action potential (AP) of the medium-size DRG cells in the OAB rat model were investigated, together with the effect of ZD7288 (2 μM) administration on said parameters. a: the amplitude of the action potential was significantly increased in OAB rats, b: the action potential half-width was significantly reduced in OAB rats, c: the amplitude of the afterhyperpolarization potential was significantly reduced in OAB rats, d: the action potential threshold value of OAB rats was significantly lowered; ZD7288 significantly reduced the threshold value of both OAB and sham-intervention rats, but did not affect the AP amplitude, half-width, and AHP amplitude. (*p < 0.05, sham vs OAB group, #p < 0.05, OAB vs OAB + ZD7288 group,; $p < 0.05, sham vs sham+ZD7288 group,; sham n = 24, sham+ZD7288 n = 24, OAB n = 19, OAB + ZD7288 n = 19

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BMC Urology

ISSN: 1471-2490

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