Table 5 Adverse effects in NAC group
Adverse effects | Khaled et al. [13] (n = 59) | Grossman et al. [12] (n = 153) | Pineiro et al. [18] (n = 62) |
|---|---|---|---|
Moderate/severe/life-threatening | |||
Granulocytopenia | NA | 35/50/0 | 5/0/0 |
Nausea or vomiting | 20/2/NA | 9/0/0 | 41/26/1 |
Stomatitis | 2/0/NA | 15/0/0 | NA |
Anemia | 2/0/NA | 9/1/0 | 3/0/0 |
Thrombocytopenia | 3/0/NA | 7/0/0 | 5/0/0 |
Diarrhea or constipation | 1/0/NA | 6/0/0 | NA |
Neutropenia | 2/0/0 | 2/0/NA | NA |
Fatigue, lethargy, and malaise | NA | 5/0/0 | NA |
Neuropathy | NA | 3/0/0 | 3/0/0 |
Renal effects | NA | 1/0/0 | 3/0/0 |