Immune molecular profiling of a multiresistant primary prostate cancer with a neuroendocrine-like phenotype: a case report

Table 2 Known genomic drivers of NEPC

Gene	Product	References
RB1	RB Transcriptional Corepressor 1	[19,20,21]
PTEN	Phosphatase and tensin homolog	[20]
CHD1	Chromodomain Helicase DNA Binding Protein 1	[19]
TP53	Tumor Protein P53	[19, 21]
BRCA2	BRCA2 DNA Repair Associated	[19]
AR	Androgen Receptor	[19, 22]
SPOP	Speckle Type BTB/POZ Protein	[19]
TMC8	Transmembrane Channel Like 8	[19]
FOXA1	Forkhead Box A1	[19]
LTBP1	Latent Transforming Growth Factor Beta Binding Protein 1	[19]
CRY1	Cryptochrome Circadian Regulator 1	[19]
BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	[19]
MYC	MYC Proto-Oncogene, BHLH Transcription Factor	[22, 23]
ERG	ETS Transcription Factor ERG	[24]
AURKA	Aurora Kinase A	[22]
E2F1	E2F Transcription Factor 1	[25]
ATR	ATR Serine/Threonine Kinase	[26]
MTOR	Mechanistic Target Of Rapamycin Kinase	[27]
EZH2	Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit	[22, 28]
PEG10	Paternally Expressed 10	[29]

ISSN: 1471-2490