Table 4 Non-disease-apparent Hunner’s IC biopsies compared to non-disease-apparent Non-Hunner’s IC biopsies
Accession ID | Gene name | Description | Fold change (FC ≥ 4) | p value (p ≤ 0.05) |
|---|---|---|---|---|
Immune and inflammatory response (up-regulated) 3 of 11 significant proteins | NDA HIC/NDA NHIC | |||
P30479 | HLA-B | Human leukocyte antigen B | 15.6 | 0.0039 |
P04839 | CYBB | Cytochromeb-245 beta chain | 8.11 | 0.0136 |
Q9UBR2 | CTSZ | Cathepsin Z | 7.88 | 0.0037 |
Protein metabolism (down-regulated) 9 of 50 significant proteins | NDA NHIC/NDA HIC | |||
P30038 | ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase | 17.9 | 0.0252 |
P06737 | PYGL | Glycogen phosphorylase | 8.13 | 0.0316 |
P31937 | HIBADH | 3-Hydroxyisobutyrate dehydrogenase | 7.73 | 0.0073 |
P53004 | BLVRA | Biliverdin reductase A | 5.57 | 0.0316 |
P51178 | PLCD1 | 1-Phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta 1 | 5.18 | 0.0093 |
Q02252 | ALDH6A1 | Methylmalonate-semialdehyde dehydrogenase | 4.66 | 0.0265 |
Q6P587 | FAHD1 | Acylpyruvase FAHD1 | 4.61 | 0.0235 |
P21397 | MAOA | Amine oxidase [Flavin-containing] A | 4.61 | 0.0117 |
P11586 | MTHFD1 | C-1-tetrahydrofolate synthase | 4.28 | 0.0107 |
Rap1 Signaling (down-regulated) 4 of 50 significant proteins | NDA NHIC/NDA HIC | |||
P11233 | RALA | Ras-related protein Ral-A | 7.11 | 0.0026 |
P35080 | PFN2 | Profilin-2 | 6.49 | 0.0124 |
P63096 | GNAI1 | Guanine nucleotide-binding protein G(i) subunit alpha-1 | 4.23 | 0.0266 |
P35222 | CTNNB1 | Catenin beta-1 | 4.04 | 0.0118 |