MicroRNA-219c-5p regulates bladder fibrosis by targeting FN1

BMC Urology

Table 3 Bladder weight, FN1 and miR-219c-5p expression in mice with different EAE scores

Variable	EAE score				F Value	P Value
Variable	0	1	2	3	F Value	P Value
Body weight/g	27.99 ± 0.56	27.91 ± 0.78	25.81 ± 1.05	25.68 ± 0.87	0.5882	0.646
Bladder weight to total body weight (%)	0.17 ± 0.01	0.20 ± 0.02	0.38 ± 0.02	0.56 ± 0.02	1002	< 0.0001
FN1	1.00 ± 0.10	1.23 ± 0.70	1.59 ± 0.14	3.01 ± 0.10	342.7	< 0.0001
miR-199a-3p	3.40 ± 0.53	2.73 ± 0.25	1.93 ± 0.40	1.03 ± 0.15	23.6	< 0.0001
miR-219c-5p	3.10 ± 0.10	1.73 ± 0.08	1.23 ± 0.06	1.00 ± 0.10	376.4	< 0.0001
miR-3572-3p	4.50 ± 0.50	3.53 ± 0.55	2.03 ± 0.25	1.03 ± 0.15	44.6	< 0.0002

Values are means ± SE; n = 3 mice/group. P < 0.05 by ANOVA among four groups; expression levels were normalized to β-actin or U6

ISSN: 1471-2490