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Table 2 Utility values at each time point and QALYs over the trial follow-up

From: Endoscopic urethrotomy versus open urethroplasty for men with bulbar urethral stricture: the OPEN randomised trial cost-effectiveness analysis

EQ-5D 5L

Urethroplasty

Urethrotomy

Mean (SD)

N

Mean (SD)

N

QALYs at 24 months after randomisation

1.75 (0.40)

55

1.76 (0.35)

54

QALYs at 24 months after randomisation (rescaled to 730 days)

1.66 (0.34)

55

1.70 (0.34)

54

QALY at 24 months after surgery

1.73 (0.54)

44

1.77 (0.34)

56

QALY at 24 months after surgery (rescaled to 730 days)

1.42 (0.40)

44

1.58 (0.30)

56

QALY at 24 months after randomisation with imputation

1.73 (0.32)

108

1.76 (0.28)

112

QALY at 24 months after randomisation with imputation (rescaled to 730 days)

1.67 (0.29)

108

1.72 (0.27)

112

QALY at 24 months after surgery with imputation

1.75 (0.37)

108

1.76 (0.29)

112

QALY at 24 months after surgery with imputation (rescaled to 730 days)

1.67 (0.30)

108

1.72 (0.26)

112

  1. QALY calculations For those participants who did not receive an initial intervention, to be included in the AUC analysis without imputation, they must have complete EQ-5D-5L data on all of the three time points: baseline, 18 months and 24 months after randomisation. For those participants who received an initial intervention, the base case analysis examined QALY over the period from baseline to 24 months after randomisation, therefore, the base case AUC analysis required complete EQ-5D-5L data at baseline and 24 months after randomisation, and at one of the data collection points of 3, 6, 9, 12 following surgery and 18 months following randomisation. Given the differences in the time lengths between randomisation and undergoing an intervention between urethroplasty and urethrotomy, sensitivity analyses also examined QALY over the period from the time prior to surgery to 24 month post-surgery, in which case the AUC analysis required complete EQ-5D-5L data at prior to surgery and 24 months after surgery, and at one of the data collection points of 3, 6, 9, 12 following surgery and 18, 24 months following randomisation
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BMC Urology

ISSN: 1471-2490

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