Skip to main content

Table 2 Factors Associated with urinary outcome trajectories assessed by the expanded prostate cancer index composite (EPIC)-50 among men in the prostatectomy, incontinence and erectile dysfunction (PIE) study

From: One-year urinary and sexual outcome trajectories among prostate cancer patients treated by radical prostatectomy: a prospective study

 

All participants n (%)

BPH-related factors

ED-related factors

Prostate size

IPSS score

BPH medication use at baseline

BPH composite measure

ED medication use at baseline

ED medication or device use at follow-up

 < 40 g

 ≥ 40 g

 < 8

 ≥ 8

No

Yes

No BPH

Any BPH

No

Yes

No

Yes

Urinary function (continence) 5 weeks post-surgery (n = 377)

Impaired

             

N

346 (91.8)

            

OR 95% CI

             

Maintained

             

N

28 (7.4)

            

OR 95% CI

             

Improved

             

N

3 (0.8)

            

OR 95% CI

             

Urinary function (continence) 12 months post-surgery (n = 347)

Impaired

             

N

145 (41.8)

57

51

53

46

129

16

63

82

137

8

46

94

OR 95% CI

 

Reference

Reference

Reference

Reference

Reference

Reference

Maintained

             

N

168 (48.4)

52

71

58

51

148

20

64

104

163

5

59

102

OR 95% CI

 

1.5 (0.9 to 2.6)

1.0 (0.6 to 1.7)

1.1 (0.5 to 2.2)

1.2 (0.8 to 2.0)

0.5 (0.2 to 1.6)

0.8 (0.5 to 1.4)

Improved

             

N

34 (9.8)

11

17

6

11

28

6

11

23

31

3

13

18

OR 95% CI

 

1.7 (0.6 to 4.0)

2.1 (0.7 to 6.2)

1.7 (0.6 to 4.8)

1.6 (0.7 to 3.5)

1.7 (0.4 to 6.6)

0.7 (0.3 to 1.5)

Incontinence-related bother 5 weeks post-surgery (n = 379)

Impaired

             

N

266 (70.3)

            

OR 95% CI

             

Maintained

             

N

110 (29.0)

            

OR 95% CI

             

Improved

             

N

3 (0.8)

            

OR 95% CI

             

Incontinence-related bother 12 months post-surgery (n = 348)

Impaired

             

N

53 (15.2)

16

22

25

14

47

6

23

30

50

3

18

33

OR 95% CI

 

Reference

Reference

Reference

Reference

Reference

Reference

Maintained

             

N

282 (81.0)

103

109

91

87

251

31

113

169

269

13

97

174

OR 95% CI

 

0.8 (0.4 to 1.5)

1.7 (0.8 to 3.5)

1 (0.4 to 2.4)

1.1 (0.6 to 2.1)

0.8 (0.2 to 2.9)

1.0 (0.5 to 1.8)

Improved

             

N

13 (3.7)

5

7

2

6

9

4

3

10

13

0

6

6

OR 95% CI

 

1.0 (0.3 to 3.8)

5.4 (1.0 to 30.2)

3.5 (0.8 to 15)

2.6 (0.6 to 10.4)

NE

0.5 (0.2 to 1.9)

Voiding dysfunction-related bother 5 weeks post-surgery (n = 380)

Impaired

             

N

238 (62.6)

93

89

91

54

212

26

109

129

226

12

126

99

OR 95% CI

 

Reference

Reference

Reference

Reference

Reference

Reference

Maintained

             

N

58 (15.3)

21

18

23

15

54

4

27

31

55

3

22

33

OR 95% CI

 

0.9 (0.4 to 1.8)

1.1 (0.5 to 2.3)

0.6 (0.2 to 1.8)

1.0 (0.5 to 1.7)

1.0 (0.3 to 3.8)

1.9 (1.0 to 3.5)

Improved

             

N

84 (22.1)

20

41

14

46

63

21

15

69

80

4

38

40

OR 95% CI

 

2.1 (1.2 to 3.9)

5.5 (2.8 to 11.0)

2.7 (1.4 to 5.2)

3.9 (2.1 to 7.2)

0.9 (0.3 to 3.0)

1.3 (0.8 to 2.2)

Voiding dysfunction-related bother 12 months post-surgery (n = 348)

Impaired

             

N

91 (26.1)

38

32

36

20

84

7

49

42

87

4

32

57

OR 95% CI

 

Reference

Reference

Reference

Reference

Reference

Reference

Maintained

             

N

80 (23.0)

37

26

35

13

75

5

44

36

76

4

22

53

OR 95% CI

 

0.8 (0.4 to 1.7)

0.7 (0.3 to 1.5)

0.8 (0.2 to 2.6)

1.0 (0.5 to 1.7)

1.1 (0.3 to 4.7)

1.4 (0.7 to 2.6)

Improved

             

N

177 (50.9)

49

80

47

74

148

29

46

131

169

8

67

103

OR 95% CI

 

1.9 (1.1 to 3.5)

2.8 (1.5 to 5.5)

2.4 (1.0 to 5.6)

3.3 (2.0 to 5.7)

1.0 (0.3 to 3.5)

0.9 (0.5 to 1.5)

  1. BPH benign prostatic hyperplasia, CI confidence interval, ED erectile dysfunction, IPSS International Prostate Symptom Score, OR odds ratio, NE not estimable
  2. EPIC-50 measured urinary and sexual outcome trajectories were defined as impaired (negative change greater than the upper bound of minimally important difference), maintained, and improved (positive change greater than the upper bound of minimally important difference). Urinary function, incontinence-related bother: impaired (change < 9); maintained (− 9 ≤ change ≤ 9); improved (change ≥ 9). Voiding dysfunction-related bother: impaired (change < 7); maintained (− 7 ≤ change ≤ 7); improved (change ≥ 7)
Back to article page

BMC Urology

ISSN: 1471-2490

Contact us