Fig. 4
From: Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer
Menadione enhanced radiation response under hypoxic conditions in DU145 cells. a Menadione (10 µM, 24 h) did not enhance the radiosensitivity of normoxic DU145 cells. b The SER of hypoxic DU145 cells treated with menadione was 1.15 and at 4 Gy menadione significantly reduced surviving fraction compared to radiation alone. c In the PC3 cell line, menadione did not enhance the radiosensitivity of normoxic or d hypoxic cells. The data points represent the mean ± SEM of 2–4 values taken from each biological repeat, within each biological repeat there were 6 intra-assay replicates. Statistical analysis was performed using a paired t-test (ns = not significant, * indicates p < 0.05). SERs were calculated at SF10% and statistical analysis was performed using the F-test