Fig. 1

Cumulative dosing of IT baclofen. a Abdominal EMG responses to graded UBD (10–60 mmHg) were quantified as a mean Area-Under-the-Curve (AUC) for each dose of baclofen tested (n = 8; cumulative doses values of 0, 10, 20, 40, 80 and 160 ng) and presented on a log scale. These responses were significantly different for AUC measures in IT saline-treated rats (n = 8). * indicates p < 0.05 for post hoc comparisons. b Stimulus–response functions for the IT baclofen used to generate the AUC data in panel A and Table 1. c Individual example of rectified electromyographic activity in a single rat before and after stated doses of IT baclofen