From: Systemic and intrathecal baclofen produce bladder antinociception in rats
Pretreaments | |||||
---|---|---|---|---|---|
NBI | No NBI | NBI | No NBI | ||
Plus ABI | No ABI | Plus ABI | No ABI | ||
Cumulative dose IP | n = 8 | n = 8 | Repeated dose IP | n = 8 | n = 8 |
Baclofen 1 mg/kg | 115.2 ± 23.4 | 113.0 ± 15.2 | Saline 1st | 142.5 ± 16.8 | 154.6 ± 9.1 |
Baclofen 2 mg/kg | 101.5 ± 25.4 | 96.0 ± 17.8* | Saline 2nd | 145.9 ± 19.5 | 156.6 ± 8.4 |
Baclofen 4 mg/kg | 57.5 ± 22.2* | 67.9 ± 15.3* | Saline 3rd | 145.5 ± 18.0 | 142.9 ± 11.2 |
Baclofen 8 mg/kg | 17.2 ± 6.8* | 21.0 ± 9.5* | Saline 4th | 156.7 ± 19.8 | 141.8 ± 8.8 |
Cumulative dose IT | n = 8 | n = 8 | Repeated dose IT | n = 6 | n = 6 |
Baclofen 10 ng | 104.6 ± 5.3 | 119.4 ± 16.4 | Saline 1st | 110.8 ± 9.3 | 111.2 ± 10.2 |
Baclofen 20 ng | 82.0 ± 7.2 | 89.2 ± 12.0 | Saline 2nd | 88.3 ± 18.2 | 94.9 ± 9.9 |
Baclofen 40 ng | 49.9 ± 11.8* | 64.7 ± 15.8* | Saline 3rd | 114.2 + 24.2 | 112.0 ± 14.9 |
Baclofen 80 ng | 24.5 ± 8.3* | 30.5 ± 15.1* | Saline 4th | 114.0 ± 25.1 | 121.1 ± 15.9 |
Baclofen 160 ng | 9.9 ± 4.6* | 9.1 ± 9.1* | Saline 5th | 93.7 ± 21.1 | 142.0 ± 22.7 |