Table 1 Dose-dependent inhibitory effects resulting from cumulative doses of baclofen versus repeated doses of saline on visceromotor responses to urinary bladder distension measured as % baseline AUC

Cumulative dose IP

n = 8

n = 8

Repeated dose IP

n = 8

n = 8

Baclofen 1 mg/kg

115.2 ± 23.4

113.0 ± 15.2

Saline 1^st

142.5 ± 16.8

154.6 ± 9.1

Baclofen 2 mg/kg

101.5 ± 25.4

96.0 ± 17.8*

Saline 2^nd

145.9 ± 19.5

156.6 ± 8.4

Baclofen 4 mg/kg

57.5 ± 22.2*

67.9 ± 15.3*

Saline 3^rd

145.5 ± 18.0

142.9 ± 11.2

Baclofen 8 mg/kg

17.2 ± 6.8*

21.0 ± 9.5*

Saline 4^th

156.7 ± 19.8

141.8 ± 8.8

Cumulative dose IT

n = 8

n = 8

Repeated dose IT

n = 6

n = 6

Baclofen 10 ng

104.6 ± 5.3

119.4 ± 16.4

Saline 1^st

110.8 ± 9.3

111.2 ± 10.2

Baclofen 20 ng

82.0 ± 7.2

89.2 ± 12.0

Saline 2^nd

88.3 ± 18.2

94.9 ± 9.9

Baclofen 40 ng

49.9 ± 11.8*

64.7 ± 15.8*

Saline 3^rd

114.2 + 24.2

112.0 ± 14.9

Baclofen 80 ng

24.5 ± 8.3*

30.5 ± 15.1*

Saline 4^th

114.0 ± 25.1

121.1 ± 15.9

Baclofen 160 ng

9.9 ± 4.6*

9.1 ± 9.1*

Saline 5^th

93.7 ± 21.1

142.0 ± 22.7