Table 3 Univariate and Multivariate Cox proportional hazard regression analysis for 5-year biochemical recurrence of prostate cancer
Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | |
Preoperative variables | ||||
Age, year | 1.015 (0.994–1.035) | 0.155 | ||
BMI, kg/m2 | 0.991 (0.951–1.034) | 0.678 | ||
ASA physical status | ||||
I | 1 (reference) | |||
II | 0.794 (0.597–1.056) | 0.112 | ||
III | 0.934 (0.451–1.934) | 0.854 | ||
Diabetes mellitus | 1.321 (0.887–1.968) | 0.171 | ||
Hypertension | 1.188 (0.887–1.592) | 0.248 | ||
Coronary artery disease | 1.421 (0.840–2.404) | 0.190 | ||
Cerebrovascular accident | 1.382 (0.651–2.937) | 0.400 | ||
Smoker | 0.933 (0.702–1.241) | 0.634 | ||
Preoperative PSA, ng/ml | 1.015 (1.013–1.018) | < 0.001* | 1.005 (1.002–1.009) | < 0.001* |
Preoperative Hb, g/dl | 0.916 (0.826–1.016) | 0.098 | ||
Intraoperative variables | ||||
Main anesthetic agent | ||||
Inhalation agent | 1 (reference) | |||
Propofol | 0.957 (0.556–1.646) | 0.874 | ||
Crystalloid, ml | 1.000 (1.000–1.000) | 0.968 | ||
Colloid, ml | 1.000 (1.000–1.001) | 0.034* | ||
Estimated blood loss, ml | 1.001 (1.000–1.001) | 0.042* | ||
Perioperative RBC transfusion | ||||
None | 1 (reference) | |||
Transfusion | 2.159 (1.107–4.211) | 0.024* | ||
Number of packed RBC | 1.335 (1.094–1.631) | 0.005* | ||
Pathological variables | ||||
Pathologic T stage | ||||
< pT3 | 1 (reference) | |||
≥ pT3 | 7.197 (5.264–9.839) | < 0.001* | 3.510 (2.426–5.078) | < 0.001* |
Pathologic N stage | ||||
Nx or N0 | 1 (reference) | |||
N1 | 7.080 (4.504–11.129) | < 0.001* | 2.337 (1.465–3.729) | < 0.001* |
Gleason score | ||||
< 8 | 1 (reference) | |||
≥ 8 | 5.478 (4.137–7.254) | < 0.001* | 2.373 (1.756–3.207) | < 0.001* |
Surgical margin positive | 4.821 (3.628–6.404) | < 0.001* | 2.010 (1.452–2.782) | < 0.001* |