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Fig. 5 | BMC Urology

Fig. 5

From: Integrated mRNA-miRNA transcriptome analysis of bladder biopsies from patients with bladder pain syndrome identifies signaling alterations contributing to the disease pathogenesis

Fig. 5

Pathway analysis using mRNAs, targeted by miRNAs regulated in BPS. A Role of miRNAs depending on the number of their appropriately regulated targets. Word cloud of up-regulated (in red) and down-regulated (in green) miRNAs, font size corresponding to the number of correctly regulated mRNAs, targeted by each specific miRNA. B Word cloud of mRNAs, targeted by dysregulated miRNAs; font size corresponds to the number of miRNAs affecting the expression of a particular mRNA. The coloured circle shows the functional groups of the affected mRNAs: most are enzymes and transcription regulators, kinases and cytokines. C Cytokines up-regulated (red) and down-regulated (green) and the targeting miRNAs. Note that some cytokines are affected by several miRNAs, and some miRNAs regulate multiple cytokine mRNAs. D EIF2 signalling pathway might be activated due to the down-regulation of miRNAs, targeting its elements. Down-regulated miRNAs are shown in green, up-regulated target genes in red. E Pathway analysis based on genes, predicted to be targeted by dysregulated miRNAs and differentially expressed in BPS. Top 10 IPA Pathways are shown (based on p value). F Pathway analysis based on all regulated mRNAs in BPS, top 10 pathways are shown

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BMC Urology

ISSN: 1471-2490

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