Table 1 Top 5 canonical IPA pathways regulated in BPS based on p value
Ingenuity canonical pathways | −log(p value) | Ratio | z-score | Molecules |
|---|---|---|---|---|
EIF2 signalling | 9.15 | 0.125 | 3.771 | DDIT3 EIF2AK3 EIF3G FAU MAP2K2 RPL10A RPL13 RPL18 RPL18A RPL24 RPL27 RPL28 RPL29 RPL35 RPL36 RPL37 RPL38 RPLP1 RPLP2 RPS15 RPS15A RPS16 RPS19 RPS21 RPS4X RPS7 RPS9 RRAS |
Hepatic fibrosis/hepatic stellate cell activation | 4.54 | 0.0968 | NA | CCL2 CCL21 CCN2 COL18A1 COL19A1 COL22A1 COL4A2 COL6A1 COL6A2 COL9A3 CXCL9 IGFBP4 MET MYL6 MYL9 STAT1 TIMP1 VEGFB |
Leukotriene biosynthesis | 3.24 | 0.308 | 2 | DPEP2 GGT1 GGT5 LTC4S |
Regulation of eIF4 and p70S6K Signalling | 2.81 | 0.0828 | NA | EIF3G FAU ITGA2 MAP2K2 RPS15 RPS15A RPS16 RPS19 RPS21 RPS4X RPS7 RPS9 RRAS |
Cholesterol biosynthesis | 2.69 | 0.172 | − 2.236 | HMGCR HMGCS1 MSMO1 SC5D SQLE |