Table 4 Semi-quantitative scoring system of p16INK4a immunostaining
Percentage of immunoreactive cells | Staining pattern | p16INK4a expression assessment | Reference |
|---|---|---|---|
0–5% | Negative | Negative | Gabrielli Fregonesi et al. [46] |
6–10% | Sporadic | Positive (low expression) | |
11–30% | Focal | Positive (moderate expression) | |
More than 30% | Diffuse | Positive (high expression) |