Impact of salvage cytotoxic chemotherapy on prognosis in patients with recurrence after radical cystectomy: a multi-institutional retrospective study

Table 2 Univariate and multivariate analyses for worse cancer-specific survival

Variable	Category	Univariate analysis			Multivariate analysis
Variable	Category	HR	95% CI	P value	HR	95% CI	P value
Age	≥ 70	1.04	0.66–1.66	0.86	1.37	0.82–2.28	0.23
Age	≤ 69	1.0			1.0
Sex	Female	1.36	0.80–2.30	0.25	1.51	0.82–2.79	0.19
Sex	Male	1.0			1.0
T stage	≥ pT3	1.47	0.88–2.46	0.14	1.92	1.06–3.46	0.03
T stage	≤ pT2	1.0			1.0
Metastasis
Liver	Positive	1.68	1.02–2.77	0.041	2.13	1.17–3.85	0.01
Liver	Negative	1.0			1.0
Lung	Positive	1.21	0.72–2.05	0.47	1.57	0.85–2.91	0.15
Lung	Negative	1.0			1.0
Lymph node	Positive	0.89	0.56–1.42	0.63	0.90	0.53–1.52	0.69
Lymph node	Negative	1.0			1.0
Bone	Positive	0.89	0.53–1.48	0.66	0.90	0.48–1.69	0.75
Bone	Negative	1.0			1.0
AC	Positive	0.76	0.46–1.24	0.27	0.53	0.27–1.03	0.06
AC	Negative	1.0			1.0
SC	Positive	0.67	0.42–1.07	0.096	0.72	0.40–1.29	0.27
SC	Negative	1.0			1.0

HR hazard ratio, CI confidence interval, TTR time to recurrence, RC radical cystectomy, AC adjuvant chemotherapy, SC salvage cytotoxic chemotherapy

ISSN: 1471-2490