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Table 3 Independent prognostic factors analyzed using a multivariable Cox model in patients with metastatic renal cell carcinoma

From: Prognostic value of the ratio of maximum to minimum diameter of primary tumor in metastatic clear cell renal cell carcinoma

Variable

Progression free survival

Overall survival

HR

95% CI

p value

HR

95% CI

p value

Presenting symptom

   

2.219

1.220–4.037

0.009

ROD, ≥ 1.34

3.068

2.102–4.478

 < 0.001

1.774

1.175–2.676

0.006

WHO/ISUP grade, III/IV

2.102

1.512–2.922

 < 0.001

2.699

1.880–3.874

 < 0.001

Tumor necrosis

1.315

0.933–1.854

0.118

2.046

1.395–3.002

 < 0.001

Sarcomatoid differentiation

1.529

1.031–2.268

0.035

1.123

0.710–1.776

0.621

MSKCC score, intermediate and poor

1.619

1.137–2.305

0.008

1.901

1.261–2.864

0.002

IMDC score, intermediate and poor

2.315

1.427–4.438

 < 0.001

2.004

1.258–4.062

 < 0.001

  1. ROD Ratio of maximum to minimum tumor diameter, WHO/ISUP World Health Organization/International Society of Urologic Pathologists, MSKCC Memorial Sloan Kettering Cancer Center, IMDC International Metastatic Renal Cell Carcinoma Database Consortium