Table 6 Analysis of MUC1 expression and CCLE/GDSC drug sensitivity correlation in BLCA
Drug | Target (s) | Spearman coefficient (ρ) | p value | |
|---|---|---|---|---|
CCLE | PLX4729 | RAF | 1 | < 0.001 |
RAF265 | Raf kinase B, KDR | 0.68 | 0.011 | |
AZD6244 | MEK | 0.63 | 0.035 | |
Nilotinib | Abl/Bcr-Abl | 0.56 | 0.046 | |
LBW242 | IAP | − 0.9 | 0.037 | |
Paclitaxel | Beta-tubulin | − 0.723 | 0.004 | |
GDSC | Bleomycin (50 μM) | DNA damage | 0.558 | 0.016 |
CCT018159 | HSP90 | 0.63 | 0.004 | |
CH5424802 | ALK | 0.5 | 0.029 | |
CP724714 | ERBB2 | 0.504 | 0.027 | |
GW441756 | NTRK1 | 0.543 | 0.045 | |
I-BET-762 | BRD2, BRD3, BRD4 | 0.518 | 0.023 | |
JNK Inhibitor VIII | JNK | 0.56 | 0.037 | |
SB590885 | BRAF | 0.579 | 0.023 | |
VX-IIe | ERK | 0.581 | 0.009 | |
VX702 | p38 | 0.618 | 0.019 | |
DMOG | Prolyl-4-Hydroxylase | − 0.505 | 0.027 | |
XAV939 | TNKS1, TNKS2 | − 0.556 | 0.017 |