Table 2 Association of TFF1 and nephrolithiasis risk in each stage
From: Association of functional genetic variants in TFF1 and nephrolithiasis risk in a Chinese population
Stage | tagSNPs | Alleles (major/minor) | Casesa | Controlsa | Adjusted OR (95% CI)b | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Co-dominant model | Additive model | Dominant model | Recessive model | Pc | Padjd | Ptrend | ||||||
Hetb | Homb | |||||||||||
Discovery | rs225355 | G > A | 147/72/11 | 151/93/6 | 0.74 (0.50–1.09) | 2.00 (0.70–5.75) | 0.81 (0.55–1.18) | 0.81 (0.55–1.18) | 2.23 (0.78–6.34) | 0.268 | 1.000 | 0.185 |
rs2839488 | C > G | 129/79/19 | 147/86/16 | 1.01 (0.68–1.51) | 1.50 (0.72–3.10) | 1.12 (0.84–1.51) | 1.08 (0.74–1.57) | 1.49 (0.73–3.04) | 0.433 | 1.000 | 0.594 | |
rs13051704 | C > G | 140/63/10 | 131/107/12 | 0.53 (0.35–0.79) | 0.70 (0.29–1.73) | 0.64 (0.46–0.89) | 0.54 (0.37–0.80) | 0.90 (0.37–2.17) | 0.008 | 0.056 | < 0.001 | |
rs225358 | C > T | 128/82/20 | 143/79/28 | 1.21 (0.81–1.81) | 0.82 (0.43–1.56) | 1.01 (0.76–1.32) | 1.11 (0.77–1.61) | 0.77 (0.41–1.43) | 0.969 | 1.000 | 0.499 | |
rs3761376 | G > A | 64/112/51 | 100/117/33 | 1.47 (0.97–2.23) | 2.21 (1.28–3.85) | 1.48 (1.14–1.94) | 1.64 (1.10–2.43) | 1.76 (1.08–2.88) | 0.004 | 0.028 | 0.003 | |
rs225359 | G > A | 121/90/19 | 144/84/22 | 1.36 (0.92–2.02) | 1.05 (0.53–2.07) | 1.15 (0.86–1.53) | 1.30 (0.90–1.88) | 0.93 (0.48–1.80) | 0.335 | 1.000 | 0.451 | |
rs35448902 | C > T | 151/65/11 | 140/97/13 | 0.63 (0.43–0.94) | 0.72 (0.30–1.69) | 0.72 (0.53–0.99) | 0.64 (0.44–0.94) | 0.84 (0.36–1.96) | 0.043 | 0.301 | 0.028 | |
Validation | rs3761376 | G > A | 108/123/66 | 186/214/61 | 0.97 (0.69–1.36) | 1.83 (1.18–2.84) | 1.28 (1.03–1.58) | 1.16 (0.85–1.59) | 1.86 (1.25–2.78) | 0.026 | – | < 0.001 |
Combined | rs3761376 | G > A | 172/235/117 | 286/331/94 | 1.15 (0.88–1.51) | 2.01 (1.42–2.85) | 1.37 (1.16–1.62) | 1.35 (1.05–1.73) | 1.86 (1.35–2.54) | < 0.001 | – | < 0.001 |