Table 3 Stratified analyses on the association between TFF1 rs3761376 and nephrolithiasis risk
From: Association of functional genetic variants in TFF1 and nephrolithiasis risk in a Chinese population
Characteristic | Cases (n = 537), n (%) | Controls (n = 711), n (%) | OR (95% CI)a | Pa | Pheterogeneity | Pinteraction | ||
|---|---|---|---|---|---|---|---|---|
GG | AG + AA | GG | AG + AA | |||||
Age, years | 0.744 | 0.152 | ||||||
≤ 46 | 73 (30.8) | 164 (69.2) | 151 (40.1) | 226 (59.9) | 1.44 (0.98–2.10) | 0.062 | ||
> 46 | 99 (34.5) | 188 (65.5) | 135 (40.4) | 199 (59.6) | 1.32 (0.92–1.88) | 0.135 | ||
Gender | 0.806 | 0.562 | ||||||
Male | 109 (30.6) | 247 (69.4) | 183 (38.7) | 290 (61.3) | 1.50 (1.09–2.08) | 0.013 | ||
Female | 63 (37.5) | 105 (62.5) | 103 (43.3) | 135 (56.7) | 1.61 (0.73–1.85) | 0.528 | ||
BMI, mg/k2 | 0.392 | 0.345 | ||||||
≤ 24 | 78 (34.7) | 147 (65.3) | 144 (40.4) | 212 (59.6) | 1.24 (0.86–1.79) | 0.241 | ||
> 24 | 80 (29.3) | 193 (70.3) | 142 (40.0) | 213 (60.0) | 1.55 (1.09–2.22) | 0.015 | ||
HP | 0.981 | 0.823 | ||||||
Yes | 45 (31.5) | 98 (68.5) | 47 (36.2) | 83 (63.8) | 1.36 (0.80–2.30) | 0.255 | ||
No | 122 (33.6) | 241 (66.4) | 238 (41.0) | 342 (59.0) | 1.35 (1.01–1.79) | 0.041 | ||
Diabetes | 0.968 | 0.882 | ||||||
Yes | 13 (43.3) | 17 (56.7) | 20 (47.6) | 22 (52.4) | 1.37 (0.47–3.98) | 0.562 | ||
No | 152 (32.0) | 323 (68.0) | 265 (39.7) | 403 (60.3) | 1.34 (1.04–1.74) | 0.027 | ||
Smoking status | 0.237 | 0.484 | ||||||
Ever | 64 (29.6) | 152 (70.4) | 82 (38.1) | 133 (61.9) | 1.68 (1.09–2.59) | 0.020 | ||
Never | 107 (35.2) | 197 (64.8) | 203 (41.0) | 292 (59.0) | 1.22 (0.90–1.66) | 0.203 | ||
Drinking status | 0.005 | 0.037 | ||||||
Ever | 49 (26.8) | 134 (73.2) | 105 (41.8) | 146 (58.2) | 2.32 (1.48–3.64) | < 0.001 | ||
Never | 122 (36.3) | 214 (63.7) | 180 (39.2) | 279 (60.8) | 1.06 (0.78–1.44) | 0.733 | ||