Table 1 Comparison of clinicopathological characteristics of 63 renal eAML patients from the FUSCC cohort
Variable | Entire group (n = 63) | No recurrence/metastasis (n = 46) | Recurrence/metastasis (n = 17) | p value |
|---|---|---|---|---|
Age (years, mean ± SD) | 40.8 ± 13.7 | 40.5 ± 13.1 | 42.0 ± 15.7 | 0.791 |
Size (cm, mean ± SD) | 7.6 ± 4.5 | 6.2 ± 3.5 | 11.4 ± 4.9 | < 0.001 |
Sex (n, %) | 0.607 | |||
Male | 31 (49.2) | 22 (47.8) | 9 (52.9) | |
Female | 32 (50.8) | 24 (52.2) | 8 (47.1) | |
Laterality (n, %) | 0.163 | |||
Left | 28 (44.4) | 18 (39.1) | 10 (58.8) | |
Right | 35 (55.5) | 28 (60.9) | 7 (41.2) | |
pT stage (n, %) | 0.003 | |||
T1–T2 | 44 (69.8) | 37 (80.4) | 7 (41.2) | |
T3–T4 | 19 (30.2) | 9 (19.6) | 10 (58.8) | |
pN stage (n, %) | 0.284 | |||
N0 | 59 (93.6) | 44 (95.7) | 15 (88.2) | |
N1 | 4 (6.3) | 2 (4.3) | 2 (11.8) | |
Surgical procedure | – | |||
RN | 36 (57.1) | 22 (47.8) | 14 (82.4) | |
NSS | 27 (42.9) | 24 (52.2) | 3 (17.6) | |
Necrosis | 0.049 | |||
Negative | 48 (76.2) | 38 (82.6) | 10 (58.8) | |
Positive | 15 (23.8) | 8 (17.4) | 7 (41.2) | |
Perinephric fat invasion (n, %) | 0.926 | |||
Negative | 59 (93.7) | 43 (93.5) | 16 (94.1) | |
Positive | 4 (6.3) | 3 (6.5) | 1 (5.9) | |
Microvascular invasion (n, %) | 0.540 | |||
Negative | 62 (98.4) | 45 (97.8) | 17 (100) | |
Positive | 1 (1.6) | 1 (2.2) | 0 (0) | |
Multiple eAML | 0.800 | |||
Single | 60 (95.2) | 44 (95.7) | 16 (94.1) | |
Multiple | 3 (4.8) | 2 (4.3) | 1 (5.9) | |
Epithelioid cells (%, average ± SD) | 85.6 ± 4.1 | 85.2 ± 4.2 | 86.8 ± 3.9 | 0.187 |
Nuclear atypia (n, %) | 0.005 | |||
Mild | 14 (22.2) | 9 (19.6) | 5 (29.4) | |
Moderate | 40 (63.5) | 34 (73.9) | 6 (35.3) | |
Severe | 9 (14.3) | 3 (6.5) | 6 (35.3) | |
Mitotic count (n, average ± SD) | 1.6 ± 1.9 | 0.7 ± 0.6 (range 0–2) | 3.6 ± 2.2 (range 1–7) | < 0.001 |
Atypical mitoses (n, %) | < 0.001 | |||
Absence | 47 (74.6) | 41 (89.1) | 6 (35.3) | |
Presence | 16 (25.4) | 5 (11.9) | 11 (64.7) | |
Multinucleated giant cells (n, %) | 0.071 | |||
Absence | 34 (54.0) | 28 (60.9) | 6 (35.3) | |
Presence | 29 (46.0) | 18 (39.1) | 11 (64.7) |