Fig. 5

PPI network construction and module analysis for DEGs. A The PPI network of DEGs was constructed, and DEGs with ≤ 3 nodes and ≤ 3 edges were removed from the network. Up-regulated genes are marked in red, and down-regulated genes are marked in green. Larger sizes or darker colors of a node indicate that the corresponding gene had a greater logFC. B Bar plot of the nodes with top 30 degrees in the PPI network. Higher numbers and longer bar lengths represent greater interactions of the protein. C The most significant module in the PPI network had 13 nodes and 77 edges. D The second most significant module in the PPI network had 14 nodes and 36 edges. E The third most significant module in the PPI network had 7 nodes and 13 edges