Fig. 8

CDH1 expression in vitro and corresponding gene identification and function analysis. A CDH1 expression in various cancer cell lines based on the CCLE database. The ordinate represents the expression level of CDH1. B Heat map of the top 20 positively and negatively co-expressed genes with CDH1 in urinary tract cancer cell lines extracted from the CCLE database. C Correlation between the expression of CDH1 and EPCAM. Cor is the correlation coefficient. D mRNA expression levels of CDH1 and EPCAM in SVHUC1 cells, and 5637 and RT4 bladder tumor cells examined using RT-PCR. Three independent experiments were conducted for each RT-PCR assay, and P < 0.05 was considered to reflect a statistically significant difference from the SVHUC1 group. E GSEA function enrichment analysis of differentially expressed genes in the high CDH1 expression group and low CDH1 expression group based on the CCLE database