Table 2 Summary of assessed immunohistochemical markers
Immunohistochemical antibodies | Usual positive staining | Result in myointimoma |
|---|---|---|
Alpha-smooth muscle actin (SMA) | Smooth muscle cells, myofibroblasts, myoepithelial cell, osteoblasts, chondrocytes, pericytes, and others | Positive |
Ki-67 | Marker of proliferative aktivity | Low (beneath 1%) |
Desmin | Myoblasts, myofibroblasts (variable), myometrium, smooth muscle cells, and others | Negative in tumor, positive in the pre-existing vessel wall |
S100 protein | Marker of cells of neuroectodermal histogenesis (neurons, schwann cells, melanocytes, glial cells), myoepithelial cells, adipocytes, Langerhans cells, dendritic cells, interdigitating dendritic cells, chondrocytes and notochordal cells | Negative |
CD34 | Endothelium of blood vessels, hematopoietic progenitor cells, and others | Negative |
ERG | Blood vessel and lymphatic endothelial cells, immature myeloid cells | Negative |