Table 4 Univariate and multivariate Cox proportional hazards regression analyses of OS

Age (years)

Continuous

1.02 (0.99–1.04) per score

Sex

Male

Reference

Female

0.78 (0.41–1.39)

ECOG PS

0

Reference

Reference

 ≥ 1

1.93 (1.15–3.18)

2.09 (1.20–3.57)

eGFR (mL/min/1.73 m²)

 < 60

Reference

 ≥ 60

1.17 (0.71–1.92)

Primary site

Bladder

Reference

Upper urinary tract

1.06 (0.63–1.82)

Both

1.85 (0.91–3.57)

Resection of primary site

No

Reference

Reference

Yes

0.49 (0.30–0.80)

0.64 (0.38–1.05)

Prior neoadjuvant/adjuvant chemotherapy

No

Reference

Yes

1.20 (0.55–2.31)

Lymph node metastasis

No

Reference

Reference

Yes

1.73 (1.05–2.95)

2.28 (1.34–4.01)

Lung metastasis

No

Reference

Yes

0.88 (0.53–1.44)

Bone metastasis

No

Reference

Yes

1.13 (0.56–2.84)

Liver metastasis

No

Reference

Reference

Yes

2.20 (1.12–3.96)

2.72 (1.35–5.09)

First-line regimens

Full-dose GC

Reference

Dose-reduced GC

1.11 (0.59–2.03)

GCa

1.25 (0.72–2.18)